Calories regulate a hormone that tells the brain when the stomach is full, and the signals get blocked when too many are eaten.
In fact, calorie-rich food will determine whether a person keeps on eating, and the weight of the person doesn’t have any influence on this.
Calories from fats or carbohydrates control the hormone, uroguanylin, which creates a feeling of fullness in the brain. But when too many are eaten, the gut stops producing the hormone even though the number of receptors in the brain may actually increase.
Researchers from the Sidney Kimmel Medical College say their discovery goes against the prevailing view that obesity is related to the production of hormones such as insulin and leptin, which the body produces in ever greater quantities as weight increases. “Here, it’s not the obese state that’s causing the problem, but rather it’s the calories,” said lead researcher Scott Waldman.